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The body quickly
builds tolerance to amphetamines with regular use, though this fades quickly with
breaks. Users have to rapidly increase doses to maintain effects. In narcoleptics
and hyperactive children, however, there is no tolerance.
Amphetamines are highly addictive, working like alcohol,
nicotine, and cocaine on the dopamine "reward" pathways of the brain.
Short term recreational use can slip unnoticed into long term systematic abuse.
Some speed addicts have had habits lasting over twenty years.
If you are addicted, withdrawal will give exactly the reverse effects
of the drug. Instead of the drug's euphoria and curbing the need to
eat and sleep, withdrawal causes excessive hunger and fatigue, different
from heroin withdrawal, but equally distressing.
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