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Thanks to its use in medicine, Ketamine is relatively
safe compared with most recreational drugs. There have been numerous
human clinical trials and its effects, long and short term, are
well documented and understood.
Nevertheless, recreational drug use is not controlled
medical use
overdosing
Overdosing on a self-administered dose of Ketamine
is nearly impossible because it has a wide safety margin and you
will pass out well before it can kill you.
However, Ketamine is not a good drug to take outside the home.
You're quite likely to fall down, get run over, or at least make a complete fool
of yourself.
Talking, moving or even going to the toilet is not easy; it's
important to be in a safe environment with, ideally, one non-participating
friend.
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physical dangers
At high doses, Ketamine can be physically incapacitating,
even paralysing. Make sure you extinguish all cigarettes, candles
and anything flammable that could be knocked over.
long term dangers
Some emerging research suggests that heavy and prolonged Ketamine
use can cause brain damage, in the form of 'Olney's lesions' or
'vacuoles.'
However these vacuoles were found on rats injected
with Ketamine and experiments on monkeys have failed to produce
similar results. This is probably one reason why the Federal Drugs
Administration (FDA) in the US has not removed medicinal Ketamine
from the marketplace. (1)

1.
Ketamine: Dreams & Realities p.241
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