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Thanks to its use in medicine, Ketamine is relatively safe compared with most recreational drugs. There have been numerous human clinical trials and its effects, long and short term, are well documented and understood. Nevertheless, recreational drug use is not controlled medical use. Overdosing on Special K Overdosing on a self-administered dose of Ketamine is nearly impossible because it has a wide safety margin and you will pass out well before it can kill you. However, Ketamine is not a good drug to take outside the home. You're quite likely to fall down, get run over, or at least make a complete fool of yourself.
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