Like all anesthetics, Ketamine is not a good mixer. Respiratory depressants like alcohol and valium are particularly risky. At anything above a low level dose (50mg or less), Ketamine is so powerful and complete that for most users, combining it with any other drug only detracts from the experience.
Please note: there have been very few scientific studies into the effects of combining psychoactive drugs. The information presented here is anecdotal. It is based on the subjective reports of experienced users. Different people will respond differently to different drugs and drug combinations. Know your body.
alcohol can cause nausea and vomiting; can also depress respiratory system at high doses
amphetamines some users add amphetamines to lower doses of Ketamine for a more MDMA/Cocaine psychedelic party drug feel
cannabis K amplifies certain cannabis effects, notably closed-eye imagery; no reported problems, but make sure you stub the joint out before taking K
ecstasy (MDMA) some like to take small K 'bumps' towards the end of their E experience; brings back the Ecstasy sensations and adds a psychedelic tinge
heroin depresses respiratory system; counters the psychedelic effects of K
LSD no reported health problems but can make a weird trip even weirder; increases K's ability to induce out of body experiences; some users report that small amounts can 'ground' the wilder aspects of LSD experience
magic mushrooms simultaneous mushroom and ketamine feelings; time slow downs; no reported health problems
tobacco in a Ketamine daze you could burn your house down
valium you can't be any more relaxed when you're on K; depressants are dangerous with Ketamine
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